The cells responsible for making skin pigment are called melanocytes.¹ In vitiligo, melanocytes are destroyed, resulting in a loss of pigment and the appearance of white patches.¹ There are many theories about what causes vitiligo, but most researchers agree that in most cases, vitiligo is an autoimmune condition.² In other words, white patches and other symptoms of vitiligo are caused by the body’s immune system attacking the melanocytes.² Different types of vitiligo may have different causes.¹

While researchers have established that both hereditary and environmental factors influence a person’s risk for developing vitiligo, no one has identified why some people get vitiligo and some people don’t.³ Most scientists believe vitiligo is most likely caused by a combination of inherited and environmental factors.⁴

In one theory, there are three processes that contribute to the development of vitiligo:⁵

1. Melanocytes are exposed to stress, which may be caused by genetic or environmental factors, or both.
2. Stressed melanocytes provoke inflammation, leading the immune system to identify them as foreign.
3. The immune system develops cells specifically to seek out and destroy melanocytes.

Research continues to identify the risk factors that contribute to the development of vitiligo.

Risk Factors for Vitiligo

It is important to note that while science is good at finding correlations, or apparent relationships, between factors and disease, correlation does not prove that the factor causes the disease. Many risk factors for vitiligo have been identified and are being studied, but none have been pinpointed as a single cause of vitiligo.

Hereditary Factors

Vitiligo does not appear to be directly inherited from parents in any clear genetic pattern. About 6 percent of people with vitiligo have a first-degree relative with vitiligo.⁶ Among identical twins, if one has vitiligo, the other has a 23 percent risk for developing the skin condition.⁷

More than 30 different genes, occurring in different combinations, appear to be associated with a risk for developing vitiligo.³ Some of these genes influence how the body regulates inflammation or how melanocytes develop.³ Research suggests that the melanocytes of people with vitiligo may be more susceptible to environmental stress, or that their immune systems may have an abnormal reaction to stressed melanocytes.³

Inherited genes that raise your risk for developing vitiligo may also raise your risk for developing some other health conditions. Read more about conditions related to vitiligo.

Environmental Factors

One theory about the cause of vitiligo is that a trigger event causes stress to melanocytes in a person who is genetically predisposed to develop vitiligo.⁸ Researchers have identified an array of environmental factors linked to the development of vitiligo. These environmental factors may trigger vitiligo to develop in some people; in most people with vitiligo, the trigger is not known.⁸

• Sunburn⁸
• Trauma to the skin, which may include repeated rubbing or scratching^8,9
• Exposure to monobenzone or a similar chemical in a class known as phenols. Monobenzone is used in producing rubber, leather, and cosmetic dyes.¹⁰ Monobenzone has been shown in multiple studies to cause vitiligo to develop and to worsen vitiligo in people who already have it.¹⁰
• Emotionally stressful events may trigger the development of vitiligo, potentially due to hormonal changes that occur when a person experiences stress.⁴ As in other autoimmune diseases, emotional stress can worsen vitiligo and cause it to become more severe.⁴

Condition Guide

• Vitiligo – An Overview
• Conditions Related to Vitiligo
• Symptoms of Vitiligo
• Treatments for Vitiligo
• Types of Vitiligo
• Vitiligo – The Path to Diagnosis

In partnership with the Global Vitiligo Foundation, which strives to improve the quality of life for individuals with vitiligo through education, research, clinical care, and community support.